Local effect of transdermal isosorbide dinitrate ointment on hand vein diameter
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چکیده
منابع مشابه
Vasodilative effect of isosorbide dinitrate ointment in complex regional pain syndrome type 1.
BACKGROUND In complex regional pain syndrome type 1 (CRPS1) vascular changes occur from the initial, inflammatory event onto the trophic signs during chronicity of the disease, resulting in blood flow disturbances and marked temperature changes. Pharmacotherapeutic treatment is generally inadequate. AIM To determine whether local application of the nitric oxide donor isosorbide dinitrate (ISD...
متن کاملGlyceryl trinitrate (nitroglycerin) ointment and isosorbide dinitrate: a review of their pharmacological properties and therapeutic use.
Sublingual glyceryl trinitrate (nitroglycerin) is the most widely used drug in the treatment of angina pectoris, but its use is limited due to its short acting effect. Recent investigations have shown that some longer acting nitrates administered orally or topically have a long acting antianginal effect. The mechanism of the antianginal effect of nitrates is multifactorial. Nitrates increase ox...
متن کاملFormulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate
The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the releas...
متن کاملNo recovery of cold complex regional pain syndrome after transdermal isosorbide dinitrate: a small controlled trial.
The microcirculation appears to be impaired in cold chronic complex regional pain syndrome (CRPS). This double-blind, placebo-controlled, randomized trial investigated the effect of the nitric oxide (NO) donor isosorbide dinitrate (ISDN) on the peripheral blood flow in patients with chronic CRPS. Twenty-four patients received 1% ISDN in Vaseline or a placebo ointment applied to the dorsum of th...
متن کاملCHRONIC USE OF ISOSORBIDE DINITRATE/Danahy,
26. Bleifeld W, Mathey D, Hanrath P, Buss H, Effert S: Infarct size estimated from serial serum creatine phosphokinase in relation to left ventricular hemodynamics. Circulation 55: 303, 1977 27. Humphries JO, Pitt B, Griffith LSC, Ducci HH, Achuff S, Baird M, Schulze RA Jr: Coronary angiography and left ventriculography in survivors of transmural and subendocardial myocardial infarction. Circul...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2001
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-001-0379-4